Signs of a sick guinea pig can include:
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Loss of appetite
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Weight loss
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Lethargy or lack of energy
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Difficulty breathing
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Sneezing or coughing
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Eye or nose discharge
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Rough, unkempt fur
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Hiding or not wanting to be handled
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Diarrhea or soft stools
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Unusual vocalizations or squealing
If you notice any of these signs in your guinea pig, it's important to consult a veterinarian for proper diagnosis and treatment.